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The noticed not enough a significant accumulation of PHN in Mind following the intraventricular administration of (+)-amphetamine and the formation of considerable quantities of PHN from (+)-POH in brain tissue in vivo supports the see that the here aromatic hydroxylation of amphetamine following its systemic administration takes place predominantly from the periphery, and that POH is then transported with the blood-Mind barrier, taken up by noradrenergic neurones in more info brain where (+)-POH is transformed from the storage vesicles by dopamine β-hydroxylase to PHN. ^
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